Genetic risk variants for childhood nephrotic syndrome and corticosteroid response.

ABSTRACT:

Introduction

The etiology of most cases of nephrotic syndrome (NS) remains unknown, therefore patients are phenotypically categorized based on response to corticosteroid therapy as steroid sensitive NS (SSNS), or steroid resistant NS (SRNS). Genetic risk factors have been identified for SSNS from unbiased genome-wide association studies (GWAS), however it is unclear if these loci are disease risk loci in other forms of NS such as SRNS. Additionally, it remains unknown if these risk loci are associated with response to therapy. Thus, we investigated the association between SSNS risk loci and therapy response in a large, multi-race cohort of children along the entire spectrum of childhood-onset NS.

Methods

We enrolled 1,000 patients with childhood-onset NS comprised of SSNS an

SUBMITTER: Cason RK 

PROVIDER: S-EPMC10588181 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature