The relationship between COVID-19, depressive disorder, and anxiety: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Previous clinical studies have found that negative mental states such as depression and anxiety are closely related to COVID-19 infection. We used Mendelian randomization (MR) to explore the relationship between depression, anxiety, and COVID-19 infection.

Methods

Our data were based on publicly available GWAS databases. The COVID-19 samples were obtained from the COVID-19 Host Genetics Initiative (HGI). The depression samples were obtained from the Psychiatric Genomics Consortium (PGC). The anxiety samples were derived from the Finngen database. We used inverse-variance weighting (IVW) as the primary analysis method, with weighted median, MR Egger, and multivariate MRI adjustment.

Results

There was no causal effect of different COVID-19 infection statuses

SUBMITTER: Zihao L 

PROVIDER: S-EPMC10622770 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature