Dataset Information

Association of serum oleic acid level with depression in American adults: a cross-sectional study.

ABSTRACT:

Background

As the most abundant fatty acid in plasma, oleic acid has been found to be associated with multiple neurological diseases; however, results from studies of the relationship between oleic acid and depression are inconsistent.

Methods

This cross-sectional study analyzed 4,459 adults from the National Health and Nutrition Examination Survey 2011-2014. The following covariates were adjusted in multivariable logistic regression models: age, sex, race/ethnicity, education level, marital status, body mass index, physical activity, smoking status, alcohol status, metabolic syndrome, omega-3 polyunsaturated fatty acids, and total cholesterol.

Results

Serum oleic acid levels were positively associated with depression. After adjusting for all covariates, for every 1 mmol/L increase in oleic acid levels, the prevalence of depression increased by 40% (unadjusted OR: 1.35, 95%CI: 1.16-1.57; adjusted OR: 1.40, 95% CI: 1.03-1.90).

Conclusions

Our study suggests that oleic acid may play a role in depression. Further research is needed to investigate the potential benefits of changing oleic acid levels for the treatment and prevention of depression.

SUBMITTER: Yin J

PROVIDER: S-EPMC10652490 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Association of serum oleic acid level with depression in American adults: a cross-sectional study.

Yin Jiahui J Li Siyuan S Li Jinling J Gong Rongpeng R Jia Zhixia Z Liu Junjun J Jin Zhi Z Yang Jiguo J Liu Yuanxiang Y

BMC psychiatry 20231116 1

<h4>Background</h4>As the most abundant fatty acid in plasma, oleic acid has been found to be associated with multiple neurological diseases; however, results from studies of the relationship between oleic acid and depression are inconsistent.<h4>Methods</h4>This cross-sectional study analyzed 4,459 adults from the National Health and Nutrition Examination Survey 2011-2014. The following covariates were adjusted in multivariable logistic regression models: age, sex, race/ethnicity, education lev ...[more]

PMID: 37974120

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Project description:Despite extensive studies conducted on the relationship between serum uric acid (UA) and bone mineral density (BMD), their association remains controversial. In this study, we investigated whether UA levels are independently associated with BMD in Chinese and American populations to elucidate their association. Herein, the data of 12,344 individuals (age > 20 years) from the National Health and Nutrition Examination Survey (2005-2018) and those of 768 individuals from the inpatient medical records and physical examination center systems of the Tertiary Class A Hospital (2021-2023) from China were included. The association between UA and BMD was analyzed by employing multivariate regression models with covariate adjustments. In addition, population description, stratified analysis, single-factor analysis, smooth-curve fitting, and threshold and saturation effect analyses were performed. After covariate adjustments, UA exhibited an association with BMD of the femur (β = 0.008, 95% confidence interval [CI] 0.001-0.015, P = 0.02), femoral neck (β = 0.011, 95% CI 0.004-0.018, P = 0.002), and lumbar spine (β = 0.014, 95% CI 0.06-0.022, P < 0.001) in American subjects. Similarly, UA exhibited association with BMD of the femur (β = 0.079, 95% CI 0.042-0.117, P < 0.001), femoral neck (β = 0.171, 95% CI 0.121-0.22, P < 0.001), and lumbar spine (β = 0.052, 95% CI 0.007-0.097, P = 0.024) in Chinese subjects. Notably, the relationship between UA levels and BMD was nonlinear. The saturated utility values for determining the UA level with BMD of the femur and femoral neck using a two-stage linear regression model were 429.9 and 468 μmol/L, respectively, in the Chinese population. In the American population, the saturated utility values of UA level with BMD of the femur, femoral neck, and lumbar spine were 410.4, 410.4, and 452 μmol/L, respectively. Altogether, the present findings suggested a positive association between the UA levels and overall BMD in adults, implying that maintaining saturated UA levels can facilitate osteoporosis prevention.China Clinical Trials Registry: MR-51-23-051741. https://www.medicalresearch.org.cn/search/research/researchViewid=c0e5f868-eca9-4c68-af58-d73460c34028 .

Project description:ObjectiveThe purposes of the study were to investigate the detailed association of serum uric acid (SUA) with visceral fat area (VFA) and body fat percentage (BFP) as calculated by bioelectrical impedance analysis (BIA) and build non-invasive diagnosis models of hyperuricaemia by combining obesity-related indicators, age and sex.MethodA total of 19 343 adults were included. Multivariable regression analysis models were employed to analyse the association of SUA with VFA and BFP. Receiver operating characteristic curves were generated to diagnose hyperuricaemia in adults.ResultsAfter fully adjusting for covariates, SUA was positively associated with VFA, BFP and body mass index (BMI) with βs of 0.447, 2.522 and 4.630 (95% CI= (0.412 to 0.482), (2.321 to 2.723) and (4.266 to 4.994)). After stratification by gender, this association persists (p<0.001). Fitted smoothing curves identified non-linear relationships between SUA and both VFA and BMI after full adjustment in males (inflection points: 93.9 cm2 and 30.9 kg/m2). A non-linear relationship also exists between SUA and BFP in females (inflection point: 34.5%). A combined model incorporating BFP, BMI, age and sex exhibited the best ability to diagnose hyperuricaemia (AUC (area under the curve) =0.805, specificity=0.602, sensitivity=0.878). For normal-weight and lean populations, individuals with hyperuricaemia tended to have higher levels of VFA and BFP in females and males, respectively (p<0.001). The combination of VFA, BFP, BMI, age and sex exhibited the best ability to diagnose hyperuricaemia in normal-weight and lean populations (AUC=0.803, specificity=0.671, sensitivity=0.836).ConclusionVFA and BFP are independent factors associated with SUA. In males, SUA shows a non-linear relationship with VFA and BMI. In females, SUA and BFP exhibit a non-linear relationship. In normal-weight and lean individuals, the accumulation of VFA and BFP may be involved in hyperuricaemia. VFA and BFP were helpful in diagnosing hyperuricaemia in adults, especially for normal-weight and lean populations.

Dataset Information

Association of serum oleic acid level with depression in American adults: a cross-sectional study.

Background

Methods

Results

Conclusions

Publications

Association of serum oleic acid level with depression in American adults: a cross-sectional study.

Similar Datasets

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