The genes significantly associated with an improved prognosis and long-term survival of glioblastoma.

ABSTRACT:

Background and purpose

Glioblastoma multiforme (GBM) is the most devastating brain tumor with less than 5% of patients surviving 5 years following diagnosis. Many studies have focused on the genetics of GBM with the aim of improving the prognosis of GBM patients. We investigated specific genes whose expressions are significantly related to both the length of the overall survival and the progression-free survival in patients with GBM.

Methods

We obtained data for 12,042 gene mRNA expressions in 525 GBM tissues from the Cancer Genome Atlas (TCGA) database. Among those genes, we identified independent genes significantly associated with the prognosis of GBM. Receiver operating characteristic (ROC) curve analysis was performed to determine the genes significant for predicting th

SUBMITTER: Yoon HG 

PROVIDER: S-EPMC10686432 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature