Elevated BMI reduces the humoral response to SARS-CoV-2 infection.

ABSTRACT:

Objective

Class III obesity (body mass index [BMI] ≥ 40 kg m^-2) significantly impairs the immune response to SARS-CoV-2 vaccination. However, the effect of an elevated BMI (≥ 25 kg m^-2) on humoral immunity to SARS-CoV-2 infection and COVID-19 vaccination remains unclear.

Methods

We collected blood samples from people who recovered from SARS-CoV-2 infection approximately 3 and 13 months of post-infection (noting that these individuals were not exposed to SARS-CoV-2 or vaccinated in the interim). We also collected blood samples from people approximately 5 months of post-second dose COVID-19 vaccination (the majority of whom did not have a prior SARS-CoV-2 infection). We measured their humoral responses to SARS-CoV-2, grouping individuals based on a BMI gr

SUBMITTER: Tong MZ 

PROVIDER: S-EPMC10693902 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature