Association of the CDH13 gene variant rs9940180 with schizophrenia risk in North Indian population.

ABSTRACT:

Background and objectives

Cadherin13 (CDH13) is an uncommon cadherin family member, lacking a transmembrane domain, and attaches via a glycosylphosphatidylinositol anchor to the peripheral surface of the cell membrane. CDH13 plays an important role in the development and maintenance of axonal growth cones, synapse morphogenesis, and the embryonic neural tube. Cadherin superfamily genes have been associated with many neuropsychiatric diseases. Studies have shown the Cadherin13 gene as a risk locus for Schizophrenia (SCZ). In this study, we investigated CDH13 gene variants rs7204454 in the promotor region and rs9940180 in the intronic region of the gene with susceptibility to SCZ risk in the population of Jammu region of J&K, India.

Methods

The genotyping

SUBMITTER: Gupta S 

PROVIDER: S-EPMC10703641 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature