Comparative Analysis of Morphological and Functional Effects of ²²⁵Ac- and ¹⁷⁷Lu-PSMA Radioligand Therapies (RLTs) on Salivary Glands.

ABSTRACT: Most Prostate Specific Membrane Antigens (PSMAs) targeting small molecules accumulate in the salivary glands (SGs), raising concerns about SG toxicity, especially after repeated therapies or therapy with ²²⁵Ac-labeled ligands. SG toxicity is assessed clinically by the severity of patient-reported xerostomia, but this parameter can be challenging to objectively quantify. Therefore, we explored the feasibility of using SG volume as a biomarker for toxicity. In 21 patients with late-stage metastatic resistant prostate cancer (mCRPC), the PSMA volume and ligand uptake of SG were analyzed retrospectively before and after two cycles of ¹⁷⁷Lu-PSMA (LuPSMA; cohort A) and before and after one cycle of ²²⁵Ac-PSMA-617 (AcPSMA, cohort B). Mean Volume-SG in cohort A was

SUBMITTER: Feuerecker B 

PROVIDER: S-EPMC10706561 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature