Preclinical evaluation of Affibody molecule for PET imaging of human pancreatic islets derived from stem cells.

ABSTRACT:

Background

Beta-cell replacement methods such as transplantation of isolated donor islets have been proposed as a curative treatment of type 1 diabetes, but widespread application is challenging due to shortages of donor tissue and the need for continuous immunosuppressive treatments. Stem-cell-derived islets have been suggested as an alternative source of beta cells, but face transplantation protocols optimization difficulties, mainly due to a lack of available methods and markers to directly monitor grafts survival, as well as their localization and function. Molecular imaging techniques and particularly positron emission tomography has been suggested as a tool for monitoring the fate of islets after clinical transplantation. The integral membrane protein DGCR2 has been demonstra

SUBMITTER: Cheung P 

PROVIDER: S-EPMC10724103 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature