Imaging the brain's immune response to alcohol with [¹¹C]PBR28 TSPO Positron Emission Tomography.

ABSTRACT: In humans, the negative effects of alcohol are linked to immune dysfunction in both the periphery and the brain. Yet acute effects of alcohol on the neuroimmune system and its relationships with peripheral immune function are not fully understood. To address this gap, immune response to an alcohol challenge was measured with positron emission tomography (PET) using the radiotracer [¹¹C]PBR28, which targets the 18-kDa translocator protein, a marker sensitive to immune challenges. Participants (n = 12; 5 F; 25-45 years) who reported consuming binge levels of alcohol (>3 drinks for females; >4 drinks for males) 1-3 months before scan day were enrolled. Imaging featured a baseline [¹¹C]PBR28 scan followed by an oral laboratory alcohol challenge over 90 min. An hour later,

SUBMITTER: Raval NR 

PROVIDER: S-EPMC10743097 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature