The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma.

ABSTRACT:

Objective

To determine whether polymorphisms of the IL10 and IL17 genes are associated with severe asthma control and bronchodilator reversibility in children and adolescents with severe asthma.

Methods

This was a cross-sectional study, nested within a prospective cohort study of patients with severe asthma. Two outcomes were evaluated: asthma control and bronchodilator reversibility. We extracted DNA from peripheral blood and genotyped three single nucleotide polymorphisms: rs3819024 and rs2275913 in the IL17A gene; and rs3024498 in the IL10 gene. For the association analyses, we performed logistic regression in three genetic models (allelic, additive, and dominant).

Results

The rs3024498 C allele in the IL10 gene was associated with failure to achieve asthma control

SUBMITTER: Vieira MIR 

PROVIDER: S-EPMC10769478 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature