Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial.

ABSTRACT:

Background

Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity.

Methods

N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for bas

SUBMITTER: Olsen T 

PROVIDER: S-EPMC10775517 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature