Causal relationship of gut microbiota with diabetic nephropathy: a Mendelian randomization analysis.

ABSTRACT:

Background

Patients with DN (diabetic nephropathy) show remarkable variations in their gut microbiota composition. However, to date, no study has shown whether a causal relationship exists between gut microbiota composition and DN.

Methods

Here, we performed a two-sample Mendelian randomization (MR) investigation for identifying causal associations of gut microbiota with DN. Gut microbiota genetic data were gathered from the recent genome-wide association study pooled data of the MiBioGen consortium, which included 24 cohorts and 18,340 individuals.

Results

IVW(Inverse variance weighting) revealed that Verrucomicrobia [odds ratio (OR) = 1.390; 95% confidence interval (CI) = 1.10-1.75; p = 0.005], Peptostreptococcaceae (OR = 1.284; 95% CI = 1.03-1.

SUBMITTER: Yan W 

PROVIDER: S-EPMC10792041 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature