Primary biliary cirrhosis and psoriasis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Primary biliary cirrhosis (PBC) and psoriasis are frequently observed to co-occur in clinical settings. However, the causal associations and underlying mechanisms between PBC and psoriasis remain poorly defined.

Methods

In this study, we conducted bidirectional MR analysis to explore the causal relationship between PBC and psoriasis using four MR methods: inverse-variance weighted, MR-Egger regression, weighted median, and weighted mode. Sensitivity analyses were carried out, employing different models and testing methods for comparison to assess the influence of heterogeneity and pleiotropy on our findings and to confirm the robustness of these results.

Results

A causal relationship between the risk of PBC and psoriasis was identified, as confirmed by IVW

SUBMITTER: Zhao D 

PROVIDER: S-EPMC10794341 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature