Galectin-3 and peripheral artery disease: a Mendelian randomization study.

ABSTRACT:

Background

Multiple clinical studies have found a significant correlation between elevated galectin-3 (Gal-3) in circulation and the diagnosis and severity of peripheral arterial disease (PAD). The current study used the Mendelian randomization (MR) technique to evaluate the possible causal relationship between Gal-3 and PAD.

Methods

Genome-wide association study (GWAS) data of Gal-3 and PAD were obtained through the MR-Base platform. Then, using Gal-3 as the exposure and PAD as the outcome, a two-sample MR analysis was performed utilizing several regression techniques, including MR-Egger regression, inverse variance weighted (IVW), weighted median, and weighted mode.

Results

Six single-nucleotide polymorphisms (SNPs) were identified and designated as instrumental var

SUBMITTER: Gou Y 

PROVIDER: S-EPMC10794734 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature