Associations between Education Years and Resting-state Functional Connectivity Modulated by APOE ε4 Carrier Status in Cognitively Normal Older Adults.

ABSTRACT:

Objective

: Cognitive reserve has emerged as a concept to explain the variable expression of clinical symptoms in the pathology of Alzheimer's disease (AD). The association between years of education, a proxy of cognitive reserve, and resting-state functional connectivity (rFC), a representative intermediate phenotype, has not been explored in the preclinical phase, considering risk factors for AD. We aimed to evaluate whether the relationship between years of education and rFC in cognitively preserved older adults differs depending on amyloid-beta deposition and APOE ε4 carrier status as effect modifiers.

Methods

: A total of 121 participants underwent functional magnetic resonance imaging, [¹⁸F] flutemetamol positron emission tomography-computed tomograph

SUBMITTER: Kim J 

PROVIDER: S-EPMC10811405 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature