Dataset Information

Associations between Education Years and Resting-state Functional Connectivity Modulated by APOE ε4 Carrier Status in Cognitively Normal Older Adults.

ABSTRACT:

Objective

: Cognitive reserve has emerged as a concept to explain the variable expression of clinical symptoms in the pathology of Alzheimer's disease (AD). The association between years of education, a proxy of cognitive reserve, and resting-state functional connectivity (rFC), a representative intermediate phenotype, has not been explored in the preclinical phase, considering risk factors for AD. We aimed to evaluate whether the relationship between years of education and rFC in cognitively preserved older adults differs depending on amyloid-beta deposition and APOE ε4 carrier status as effect modifiers.

Methods

: A total of 121 participants underwent functional magnetic resonance imaging, [¹⁸F] flutemetamol positron emission tomography-computed tomography, APOE genotyping, and a neuropsychological battery. Potential interactions between years of education and AD risk factors for rFC of AD-vulnerable neural networks were assessed with whole-brain voxel-wise analysis.

Results

: We found a significant education years-by-APOE ε4 carrier status interaction for the rFC from the seed region of the central executive (CEN) and dorsal attention networks. Moreover, there was a significant interaction of rFC between right superior occipital gyrus and the CEN seed region by APOE ε4 carrier status for memory performances and overall cognitive function.

Conclusion

: In preclinical APOE ε4 carriers, higher years of education were associated with higher rFC of the AD vulnerable network, but this contributed to lower cognitive function. These results contribute to a deeper understanding of the impact of cognitive reserve on sensitive functional intermediate phenotypic markers in the preclinical phase of AD.

SUBMITTER: Kim J

PROVIDER: S-EPMC10811405 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

Associations between Education Years and Resting-state Functional Connectivity Modulated by <i>APOE</i> ε4 Carrier Status in Cognitively Normal Older Adults.

Kim Jiwon J Kim Sunghwan S Um Yoo Hyun YH Wang Sheng-Min SM Kim Regina Ey RE Choe Yeong Sim YS Lee Jiyeon J Kim Donghyeon D Lim Hyun Kook HK Lee Chang Uk CU Kang Dong Woo DW

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 20231120 1

<h4>Objective</h4>: Cognitive reserve has emerged as a concept to explain the variable expression of clinical symptoms in the pathology of Alzheimer's disease (AD). The association between years of education, a proxy of cognitive reserve, and resting-state functional connectivity (rFC), a representative intermediate phenotype, has not been explored in the preclinical phase, considering risk factors for AD. We aimed to evaluate whether the relationship between years of education and rFC in cognit ...[more]

PMID: 38247423

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