The relationship between circulating metabolites and prostate hyperplasia: a Mendelian randomization study.

ABSTRACT:

Background

Circulating metabolites (CM) play a pivotal role in our overall health, yet the current evidence concerning the involvement of diverse CM in benign prostatic hyperplasia (BPH) remains limited. Mendelian randomization (MR) offers a promising avenue to explore the potential impact of CM on BPH.

Methods

In a forward MR analysis, a cohort of 249 circulating metabolites was employed as exposures to investigate their potential associations with BPH risk. Conversely, in a reverse MR analysis, BPH was employed as an exposure to assess its effects on CM.

Results

The forward MR analysis discerned a linkage between six metabolites and BPH, with careful consideration to excluding heterogeneity and pleiotropy. Subsequently, the reverse MR analysis unveiled that nine met

SUBMITTER: Zhang ZC 

PROVIDER: S-EPMC10822814 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature