Dataset Information

The relationship between circulating metabolites and prostate hyperplasia: a Mendelian randomization study.

ABSTRACT:

Background

Circulating metabolites (CM) play a pivotal role in our overall health, yet the current evidence concerning the involvement of diverse CM in benign prostatic hyperplasia (BPH) remains limited. Mendelian randomization (MR) offers a promising avenue to explore the potential impact of CM on BPH.

Methods

In a forward MR analysis, a cohort of 249 circulating metabolites was employed as exposures to investigate their potential associations with BPH risk. Conversely, in a reverse MR analysis, BPH was employed as an exposure to assess its effects on CM.

Results

The forward MR analysis discerned a linkage between six metabolites and BPH, with careful consideration to excluding heterogeneity and pleiotropy. Subsequently, the reverse MR analysis unveiled that nine metabolic compounds, mainly comprising phospholipids and triglycerides, potentially exhibit elevated levels in BPH patients.

Conclusion

Bidirectional MR analysis furnishes genetic insight into the interplay between CM and BPH. The prominence of lipids and triglycerides emerges as significant factors intricately linked to BPH risk.

SUBMITTER: Zhang ZC

PROVIDER: S-EPMC10822814 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

The relationship between circulating metabolites and prostate hyperplasia: a Mendelian randomization study.

Zhang Ze-Chao ZC Huang Shu-Ping SP Lin Ze-Sen ZS Chen Yu Y Jiang Peng P Yang Yu-Wei YW Shang Chang-Jie CJ Zhu Min M Gao Hong-Jun HJ

Aging clinical and experimental research 20240128 1

<h4>Background</h4>Circulating metabolites (CM) play a pivotal role in our overall health, yet the current evidence concerning the involvement of diverse CM in benign prostatic hyperplasia (BPH) remains limited. Mendelian randomization (MR) offers a promising avenue to explore the potential impact of CM on BPH.<h4>Methods</h4>In a forward MR analysis, a cohort of 249 circulating metabolites was employed as exposures to investigate their potential associations with BPH risk. Conversely, in a reve ...[more]

PMID: 38281223

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Dataset Information

The relationship between circulating metabolites and prostate hyperplasia: a Mendelian randomization study.

Background

Methods

Results

Conclusion

Publications

The relationship between circulating metabolites and prostate hyperplasia: a Mendelian randomization study.

Similar Datasets

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