BATF and BATF3 deficiency alters CD8+ effector/exhausted T cells balance in skin transplantation.

ABSTRACT:

Background

It is well-established that CD8⁺ T-cells play a critical role in graft rejection. The basic leucine zipper ATF-like transcription factor (BATF) and BATF3 are transcriptional factors expressed in T lymphocytes. Herein, we investigated the functions of BATF and BATF3 in the differentiation and exhaustion of CD8⁺ T cells following alloantigen activation.

Methods

Wild-type CD8⁺ T cells, BATF-deficient (Batf^-/-) CD8⁺ T cells, and CD8⁺ T cells deficient in both BATF and BATF3 (Batf^-/-Batf3^-/-) were transferred to B6.Rag1^-/- mice, which received skin allografts from BALB/c mice. Flow cytometry was conducted to investigate the number of CD8⁺ T cells and the percen

SUBMITTER: Li C 

PROVIDER: S-EPMC10832090 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature