Exploring reciprocal causation: bidirectional mendelian randomization study of gut microbiota composition and thyroid cancer.

ABSTRACT:

Background

While an association between gut microbiota composition and thyroid cancer (TC) has been observed, the directionality and causality of this relationship remain unclear.

Methods

We conducted a bidirectional two-sample Mendelian randomization (MR) analysis to investigate the causal effect between gut microbiota composition and TC. Gut microbiota data were derived from a diverse population encompassing various ethnicities (n = 18,340 samples), while TC data were sourced from an European population (n = 218,792 samples). Instrumental variables, represented by single nucleotide polymorphisms (SNPs), were employed to assess the causal relationship using multiple MR methods, including inverse-variance weighting (IVW), weighted median, weighted mode, MR-Egger, and simple

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10838232 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature