Exploring Causal Relationships Between Gut Microbiota and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study.

ABSTRACT:

Background

Many observational studies have investigated the link between the gut microbiota and Alzheimer's disease (AD), but the causality remains uncertain.

Objective

This study aimed to evaluate the causal impact of gut microbiota on AD.

Methods

A two-sample Mendelian randomization (MR) study was conducted employing summary data. Summary statistics for AD were from the latest genome-wide association study (cases and proxy cases: 85,934; controls: 401,577). Summary data for gut microbiota were acquired from MiBioGen consortium. Causal effect estimations primarily relied on the inverse variance weighting method along with the sensitivity analyses for testing for pleiotropy and heterogeneity. Additionally, reverse MR analyses were performed to examine potential revers

SUBMITTER: Chen A 

PROVIDER: S-EPMC11305842 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature