Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis.

ABSTRACT:

Background

Human gut microbiome has complex relationships with the host, contributing to metabolism, immunity, and carcinogenesis.

Methods

Summary-level data for gut microbiota and metabolites were obtained from MiBioGen, FINRISK and human metabolome consortia. Summary-level data for colorectal cancer were derived from a genome-wide association study meta-analysis. In forward Mendelian randomization (MR), we employed genetic instrumental variables (IV) for 24 gut microbiota taxa and six bacterial metabolites to examine their causal relationship with colorectal cancer. We also used a lenient threshold for nine apriori gut microbiota taxa as secondary analyses. In reverse MR, we explored association between genetic liability to colorectal neoplasia and abundance of microbiota

SUBMITTER: Li W 

PROVIDER: S-EPMC10233354 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature