Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies.

ABSTRACT:

Background

Fluoride may be a developmental neurotoxicant at elevated exposures. We merged new data from a prospective Odense Child Cohort (OCC) with results from two previous birth cohort studies from Mexico and Canada to characterize the dose-effect relationship in greater detail.

Methods

The OCC contributed 837 mother-child pairs to the total of >1500. We measured creatinine-adjusted urine-fluoride concentrations in maternal urine samples obtained during late pregnancy. Child IQ was determined at age 7 years using an abbreviated version of the Wechsler Intelligence Scales for Children. Findings from the three cohorts were used to calculate the joint benchmark concentration (BMC) and the lower confidence limit (BMCL) after adjustment for covariables.

Results

In the O

SUBMITTER: Grandjean P 

PROVIDER: S-EPMC10843960 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature