Detection of the DNA methylation of seven genes contribute to the early diagnosis of lung cancer.

ABSTRACT:

Background

Low-dose Computed Tomography (CT) is used for the detection of pulmonary nodules, but the ambiguous risk evaluation causes overdiagnosis. Here, we explored the significance of the DNA methylation of 7 genes including TAC1, CDO1, HOXA9, ZFP42, SOX17, RASSF1A and SHOX2 in the blood cfDNA samples in distinguishing lung cancer from benign nodules and healthy individuals.

Method

A total of 149 lung cancer patients [72 mass and 77 ground-glass nodules (GGNs)], 5 benign and 48 healthy individuals were tested and analyzed in this study. The lasso-logistic regression model was built for distinguishing cancer and control/healthy individuals or IA lung cancer and non-IA lung cancer cases.

Results

The positive rates of methylation of 7 genes were higher in the cancer g

SUBMITTER: Du C 

PROVIDER: S-EPMC10844440 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature