Association of Plasma Claudin-5 with Age and Alzheimer Disease.
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ABSTRACT:
SUBMITTER: Tachibana K
PROVIDER: S-EPMC10855409 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
Association of Plasma Claudin-5 with Age and Alzheimer Disease.
Tachibana Keisuke K Hirayama Ryuichi R Sato Naoyuki N Hattori Kotaro K Kato Takashi T Takeda Hiroyuki H Kondoh Masuo M
International journal of molecular sciences 20240124 3
The blood-brain barrier (BBB) plays pivotal roles in synaptic and neuronal functioning by sealing the space between adjacent microvascular endothelial cells. BBB breakdown is present in patients with mild cognitive impairment (MCI) or Alzheimer disease (AD). Claudin-5 (CLDN-5) is a tetra-spanning protein essential for sealing the intercellular space between adjacent endothelial cells in the BBB. In this study, we developed a blood-based assay for CLDN-5 and investigated its diagnostic utility us ...[more]
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Project description: Not available
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