Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice.

ABSTRACT:

Background

The monthly regeneration of human endometrial tissue is maintained by the presence of human endometrial mesenchymal stromal/stem cells (eMSC), a cell population co-expressing the perivascular markers CD140b and CD146. Endometrial regeneration is impaired in the presence of intrauterine adhesions, leading to infertility, recurrent pregnancy loss and placental abnormalities. Several types of somatic stem cells have been used to repair the damaged endometrium in animal models, reporting successful pregnancy. However, the ability of endometrial stem cells to repair the damaged endometrium remains unknown.

Methods

Electrocoagulation was applied to the left uterine horn of NOD/SCID mice causing endometrial injury. Human eMSC or PBS was then injected into the left injure

SUBMITTER: Li T 

PROVIDER: S-EPMC10863157 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature