Hemodynamic Failure Staging With Blood Oxygenation Level-Dependent Cerebrovascular Reactivity and Acetazolamide-Challenged (¹⁵O-)H₂O-Positron Emission Tomography Across Individual Cerebrovascular Territories.

ABSTRACT:

Background

Staging of hemodynamic failure (HF) in symptomatic patients with cerebrovascular steno-occlusive disease is required to assess the risk of ischemic stroke. Since the gold standard positron emission tomography-based perfusion reserve is unsuitable as a routine clinical imaging tool, blood oxygenation level-dependent cerebrovascular reactivity (BOLD-CVR) with CO₂ is a promising surrogate imaging approach. We investigated the accuracy of standardized BOLD-CVR to classify the extent of HF.

Methods and results

Patients with symptomatic unilateral cerebrovascular steno-occlusive disease, who underwent both an acetazolamide challenge (¹⁵O-)H₂O-positron emission tomography and BOLD-CVR examination, were included. HF staging of vascular ter

SUBMITTER: Sebok M 

PROVIDER: S-EPMC10863778 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature