Dataset Information

The Usefulness of ¹⁸F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis.

ABSTRACT:

Background and purpose

Dementia subtypes, including Alzheimer's dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography (¹⁸F-FDG PET) in differentiating these subtypes for precise treatment and management.

Methods

A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of ¹⁸F-FDG PET in dementia. The search included studies up to November 16, 2022, focusing on peer-reviewed journals and applying the gold-standard clinical diagnosis for dementia subtypes.

Results

From 12,815 articles, 14 were selected for final analysis. For AD versus FTD, the sensitivity was 0.96 (95% confidence interval [CI], 0.88-0.98) and specificity was 0.84 (95% CI, 0.70-0.92). In the case of AD versus DLB, 18F-FDG PET showed a sensitivity of 0.93 (95% CI 0.88-0.98) and specificity of 0.92 (95% CI, 0.70-0.92). Lastly, when differentiating AD from non-AD dementias, the sensitivity was 0.86 (95% CI, 0.80-0.91) and the specificity was 0.88 (95% CI, 0.80-0.91). The studies mostly used case-control designs with visual and quantitative assessments.

Conclusions

¹⁸F-FDG PET exhibits high sensitivity and specificity in differentiating dementia subtypes, particularly AD, FTD, and DLB. This method, while not a standalone diagnostic tool, significantly enhances diagnostic accuracy in uncertain cases, complementing clinical assessments and structural imaging.

SUBMITTER: Na S

PROVIDER: S-EPMC10864694 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

The Usefulness of <sup>18</sup>F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis.

Na Seunghee S Kang Dong Woo DW Kim Geon Ha GH Kim Ko Woon KW Kim Yeshin Y Kim Hee-Jin HJ Park Kee Hyung KH Park Young Ho YH Byeon Gihwan G Suh Jeewon J Shin Joon Hyun JH Shim YongSoo Y Yang YoungSoon Y Um Yoo Hyun YH Oh Seong-Il SI Wang Sheng-Min SM Yoon Bora B Yoon Hai-Jeon HJ Lee Sun Min SM Lee Juyoun J Lee Jin San JS Rhee Hak Young HY Lim Jae-Sung JS Jung Young Hee YH Chin Juhee J Hong Yun Jeong YJ Jang Hyemin H Choi Hongyoon H Choi Miyoung M Jang Jae-Won JW

Dementia and neurocognitive disorders 20240131 1

<h4>Background and purpose</h4>Dementia subtypes, including Alzheimer's dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography (<sup>18</sup>F-FDG PET) in differentiating these subtypes for precise treatment and management.<h4>Methods</h4>A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses gui ...[more]

PMID: 38362056

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Dataset Information

The Usefulness of ¹⁸F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis.

Background and purpose

Methods

Results

Conclusions

Publications

The Usefulness of <sup>18</sup>F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

The Usefulness of 18F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis.

Background and purpose

Methods

Results

Conclusions

Publications

The Usefulness of <sup>18</sup>F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

The Usefulness of ¹⁸F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis.