Mannose and glycine: Metabolites with potentially causal implications in chronic kidney disease pathogenesis.

ABSTRACT:

Background

Chronic Kidney Disease (CKD) represents a global health challenge, with its etiology and underlying mechanisms yet to be fully elucidated. Integrating genomics with metabolomics can offer insights into the putatively causal relationships between serum metabolites and CKD.

Methods

Utilizing bidirectional Mendelian Randomization (MR), we assessed the putatively causal associations between 486 serum metabolites and CKD. Genetic data for these metabolites were sourced from comprehensive genome-wide association studies, and CKD data were obtained from the CKDGen Consortium.

Results

Our analysis identified four metabolites with a robust association with CKD risk, of which mannose and glycine showed the most reliable causal relationships. Pathway analysis spotligh

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10866514 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature