The synergism of SMC1A cohesin gene silencing and bevacizumab against colorectal cancer.

ABSTRACT:

Background

SMC1A is a subunit of the cohesin complex that participates in many DNA- and chromosome-related biological processes. Previous studies have established that SMC1A is involved in cancer development and in particular, is overexpressed in chromosomally unstable human colorectal cancer (CRC). This study aimed to investigate whether SMC1A could serve as a therapeutic target for CRC.

Methods

At first, we studied the effects of either SMC1A overexpression or knockdown in vitro. Next, the outcome of SMC1A knocking down (alone or in combination with bevacizumab, a monoclonal antibody against vascular endothelial growth factor) was analyzed in vivo.

Results

We found that SMC1A knockdown affects cell proliferation and reduces the ability to grow in anchorage-independe

SUBMITTER: Di Nardo M 

PROVIDER: S-EPMC10870497 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature