Individual differences in GHB consumption in a new voluntary GHB self-administration model in outbred rats.

ABSTRACT:

Background and purpose

The use of the recreational drug gamma-hydroxybutyric acid (GHB) has increased over the past decade, concomitantly leading to a higher incidence of GHB use disorder. Evidence-based treatment interventions are hardly available and cognitive effects of long-term GHB use remain elusive. In order to study the development of GUD and the causal effects of chronic GHB consumption, a GHB self-administration model is required.

Experimental approach

Long Evans rats had access to GHB in their home cage according to a two-bottle choice procedure for 3 months. Intoxication and withdrawal symptoms were assessed using an automated sensor-based setup for longitudinal behavioral monitoring. Rats were trained in an operant environment according to a fixed ratio (FR) 1,

SUBMITTER: Wolf CJH 

PROVIDER: S-EPMC10884067 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature