Dataset Information

Investigating the causal relationship between human blood/urine metabolites and periodontal disease using two-sample Mendelian randomization.

ABSTRACT:

Background and aims

The aim is to investigate the cause-and-effect connection between metabolites found in blood/urine and the likelihood of developing periodontal disease (PD) through the utilization of a two-sample Mendelian randomization (MR) method.

Methods

Using an inverse variance weighted (IVW) method and two additional two-sample MR models, we examined the relationship between blood/urine metabolites and PD by analyzing data from a comprehensive metabolome-based genome-wide association study and the Genome-Wide Association Studies (GWAS) of PD. To assess the consistency and dependability of the findings, diversity, cross-effects, and sensitivity analyses were conducted.

Results

Out of the 35 metabolites found in blood and urine, a total of eight metabolites (C-reactive protein, Potassium in urine, Urea, Cystatin C, Non-albumin protein, Creatinine, estimated Glomerular Filtration Rate, and Phosphate) displayed a possible causal connection with the risk of dental caries/PD using the inverse variance weighted (IVW) method (p < 0.05). This includes five metabolites in the blood and three in the urine. No metabolites were statistically significant in IVW MR models (p < 3.68 × 10^- ⁴). Even after conducting sensitivity analysis with the leave-one-out method and removing the confounding instrumental variables, the impact of these factors on dental caries/PD remained significant.

Conclusion

Based on the available evidence, it is not possible to establish a significant causal link between the 35 blood metabolites and the likelihood of developing dental caries and PD.

SUBMITTER: Yin X

PROVIDER: S-EPMC10925816 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Investigating the causal relationship between human blood/urine metabolites and periodontal disease using two-sample Mendelian randomization.

Yin Xinhai X Wu Yadong Y Song Jukun J

Health science reports 20240310 3

<h4>Background and aims</h4>The aim is to investigate the cause-and-effect connection between metabolites found in blood/urine and the likelihood of developing periodontal disease (PD) through the utilization of a two-sample Mendelian randomization (MR) method.<h4>Methods</h4>Using an inverse variance weighted (IVW) method and two additional two-sample MR models, we examined the relationship between blood/urine metabolites and PD by analyzing data from a comprehensive metabolome-based genome-wid ...[more]

PMID: 38469110

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Dataset Information

Investigating the causal relationship between human blood/urine metabolites and periodontal disease using two-sample Mendelian randomization.

Background and aims

Methods

Results

Conclusion

Publications

Investigating the causal relationship between human blood/urine metabolites and periodontal disease using two-sample Mendelian randomization.

Similar Datasets

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