Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease: A Large European Prospective Cohort.

ABSTRACT:

Background

Metals have been postulated as environmental concerns in the etiology of Parkinson's disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality.

Objective

The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk.

Methods

A case-control study was nested in a prospective European cohort, using erythrocyte samples collected before PD diagnosis.

Results

Most assessed metals were not associated with PD risk. Cadmium has a suggestive negative association with PD (odds ratio [95% confidence interval] for the highest quartile, 0.70 [0.42-1.17]), which diminished among never smokers. Among current smokers only, lead was associated with decreased PD ris

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10946475 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature