Directly Bound Deuterons Increase X-Nuclei Hyperpolarization using Dynamic Nuclear Polarization.

ABSTRACT: Deuterated ¹³ C sites in sugars (D-glucose and 2-deoxy-D-glucose) showed 6.3-to-17.5-fold higher solid-state dynamic nuclear polarization (DNP) levels than their respective protonated sites at 3.35T. This effect was found to be unrelated to the protonation of the bath. Deuterated ¹⁵ N in sites bound to exchangeable protons ([¹⁵ N₂ ]urea) showed a 1.3-fold higher polarization than their respective protonated sites at the same magnetic field. This relatively smaller effect was attributed to incomplete deuteration of the ¹⁵ N sites due to the solvent mixture. For a ¹⁵ N site that is not bound to protons or deuterons ([¹⁵ N]nitrate), deuteration of the bath did not affect the polarization level. These findings suggest a phenomenon related to DNP of X-nuclei directly bound to deuteron(s) as opposed to proton(s). It appears that direct binding to deuterons increases the solid-state DNP polarization level of X-nuclei which are otherwise bound to protons.

SUBMITTER: Rooney CHE 

PROVIDER: S-EPMC10947409 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature