Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome.

ABSTRACT:

Objective

Growth differentiation factor-9 (GDF9) and bone morphogenetic protein-15 (BMP15) are critical paracrine regulators of female fertility and are predominantly expressed by oocytes. However, it is unknown if serum concentrations reflect changes in ovarian function and/or reproductive endocrine disorders. This study aimed to determine if serum GDF9/BMP15 are associated with ovarian, pituitary, oestrogenic, androgenic and metabolic characteristics and the ovarian pathologies, polycystic ovarian morphology (PCOM) and polycystic ovary syndrome (PCOS).

Design

Women aged 21-45 years (n = 381) were included from a cross-sectional study at the National University Hospital, Singapore.

Patients

Participants were volunteers and patients with possible PCOS.

Measurements

SUBMITTER: Riepsamen AH 

PROVIDER: S-EPMC10952143 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature