Population of invasive group A streptococci isolates from a German tertiary care center is dominated by the hypertoxigenic virulent M1_UK genotype.

ABSTRACT:

Purpose

Hypertoxigenic Streptococcus pyogenes emm1 lineage M1_UK has recently been associated with upsurges of invasive infections and scarlet fever in several countries, but whole-genome sequencing surveillance data of lineages circulating in Germany is lacking. In this study, we investigated recent iGAS isolates from our laboratory at a German tertiary care center for the presence of the M1_UK lineage.

Methods

Whole-genome sequencing was employed to characterize a collection of 47 consecutive non-copy isolates recovered from blood cultures (21) and tissue samples (26) in our laboratory between October 2022 and April 2023.

Results

M protein gene (emm) typing distinguished 14 different emm types, with emm1 (17) being the dominant type. Single-nucle

SUBMITTER: Wolters M 

PROVIDER: S-EPMC10954911 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature