Plasma metabolites and risk of myocardial infarction: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Myocardial infarction (MI) is a critical cardiovascular event with multifaceted etiology, involving several genetic and environmental factors. It is essential to understand the function of plasma metabolites in the development of MI and unravel its complex pathogenesis.

Methods

This study employed a bidirectional Mendelian randomization (MR) approach to investigate the causal relationships between plasma metabolites and MI risk. We used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice versa. In addition, the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite (1400 metabolites) and

SUBMITTER: Li DH 

PROVIDER: S-EPMC10964012 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature