Dataset Information

Common infections and neuroimaging markers of dementia in three UK cohort studies.

ABSTRACT:

Introduction

We aimed to investigate associations between common infections and neuroimaging markers of dementia risk (brain volume, hippocampal volume, white matter lesions) across three population-based studies.

Methods

We tested associations between serology measures (pathogen serostatus, cumulative burden, continuous antibody responses) and outcomes using linear regression, including adjustments for total intracranial volume and scanner/clinic information (basic model), age, sex, ethnicity, education, socioeconomic position, alcohol, body mass index, and smoking (fully adjusted model). Interactions between serology measures and apolipoprotein E (APOE) genotype were tested. Findings were meta-analyzed across cohorts (N_main = 2632; N_{APOE-interaction} = 1810).

Results

Seropositivity to John Cunningham virus associated with smaller brain volumes in basic models (β = -3.89 mL [-5.81, -1.97], P_adjusted < 0.05); these were largely attenuated in fully adjusted models (β = -1.59 mL [-3.55, 0.36], P = 0.11). No other relationships were robust to multiple testing corrections and sensitivity analyses, but several suggestive associations were observed.

Discussion

We did not find clear evidence for relationships between common infections and markers of dementia risk. Some suggestive findings warrant testing for replication.

SUBMITTER: Green RE

PROVIDER: S-EPMC10984486 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Common infections and neuroimaging markers of dementia in three UK cohort studies.

Green Rebecca E RE Sudre Carole H CH Warren-Gash Charlotte C Butt Julia J Waterboer Tim T Hughes Alun D AD Schott Jonathan M JM Richards Marcus M Chaturvedi Nish N Williams Dylan M DM

Alzheimer's & dementia : the journal of the Alzheimer's Association 20240122 3

<h4>Introduction</h4>We aimed to investigate associations between common infections and neuroimaging markers of dementia risk (brain volume, hippocampal volume, white matter lesions) across three population-based studies.<h4>Methods</h4>We tested associations between serology measures (pathogen serostatus, cumulative burden, continuous antibody responses) and outcomes using linear regression, including adjustments for total intracranial volume and scanner/clinic information (basic model), age, s ...[more]

PMID: 38248636

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Dataset Information

Common infections and neuroimaging markers of dementia in three UK cohort studies.

Introduction

Methods

Results

Discussion

Publications

Common infections and neuroimaging markers of dementia in three UK cohort studies.

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