Common infections and neuroimaging markers of dementia in three UK cohort studies.

ABSTRACT:

Introduction

We aimed to investigate associations between common infections and neuroimaging markers of dementia risk (brain volume, hippocampal volume, white matter lesions) across three population-based studies.

Methods

We tested associations between serology measures (pathogen serostatus, cumulative burden, continuous antibody responses) and outcomes using linear regression, including adjustments for total intracranial volume and scanner/clinic information (basic model), age, sex, ethnicity, education, socioeconomic position, alcohol, body mass index, and smoking (fully adjusted model). Interactions between serology measures and apolipoprotein E (APOE) genotype were tested. Findings were meta-analyzed across cohorts (N_main  = 2632; N_{APOE-interaction}

SUBMITTER: Green RE 

PROVIDER: S-EPMC10984486 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature