Paired electrocatalysis unlocks cross-dehydrogenative coupling of C(sp³)-H bonds using a pentacoordinated cobalt-salen catalyst.

ABSTRACT: Cross-dehydrogenative coupling of C(sp³)-H bonds is an ideal approach for C(sp³)-C(sp³) bond construction. However, conventional approaches mainly rely on a single activation mode by either stoichiometric oxidants or electrochemical oxidation, which would lead to inferior selectivity in the reaction between similar C(sp³)-H bonds. Herein we describe our development of a paired electrocatalysis strategy to access an unconventional selectivity in the cross-dehydrogenative coupling of alcoholic α C(sp³)-H with allylic (or benzylic) C-H bonds, which combines hydrogen evolution reaction catalysis with hydride transfer catalysis. To maximize the synergistic effect of the catalyst combinations, a HER catalyst pentacoordinated Co-salen is disc

SUBMITTER: Liu K 

PROVIDER: S-EPMC10995126 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature