Dataset Information

Association of adrenal steroids with metabolomic profiles in patients with primary and endocrine hypertension.

ABSTRACT:

Introduction

Endocrine hypertension (EHT) due to pheochromocytoma/paraganglioma (PPGL), Cushing's syndrome (CS), or primary aldosteronism (PA) is linked to a variety of metabolic alterations and comorbidities. Accordingly, patients with EHT and primary hypertension (PHT) are characterized by distinct metabolic profiles. However, it remains unclear whether the metabolomic differences relate solely to the disease-defining hormonal parameters. Therefore, our objective was to study the association of disease defining hormonal excess and concomitant adrenal steroids with metabolomic alterations in patients with EHT.

Methods

Retrospective European multicenter study of 263 patients (mean age 49 years, 50% females; 58 PHT, 69 PPGL, 37 CS, 99 PA) in whom targeted metabolomic and adrenal steroid profiling was available. The association of 13 adrenal steroids with differences in 79 metabolites between PPGL, CS, PA and PHT was examined after correction for age, sex, BMI, and presence of diabetes mellitus.

Results

After adjustment for BMI and diabetes mellitus significant association between adrenal steroids and metabolites - 18 in PPGL, 15 in CS, and 23 in PA - were revealed. In PPGL, the majority of metabolite associations were linked to catecholamine excess, whereas in PA, only one metabolite was associated with aldosterone. In contrast, cortisone (16 metabolites), cortisol (6 metabolites), and DHEA (8 metabolites) had the highest number of associated metabolites in PA. In CS, 18-hydroxycortisol significantly influenced 5 metabolites, cortisol affected 4, and cortisone, 11-deoxycortisol, and DHEA each were linked to 3 metabolites.

Discussions

Our study indicates cortisol, cortisone, and catecholamine excess are significantly associated with metabolomic variances in EHT versus PHT patients. Notably, catecholamine excess is key to PPGL's metabolomic changes, whereas in PA, other non-defining adrenal steroids mainly account for metabolomic differences. In CS, cortisol, alongside other non-defining adrenal hormones, contributes to these differences, suggesting that metabolic disorders and cardiovascular morbidity in these conditions could also be affected by various adrenal steroids.

SUBMITTER: Knuchel R

PROVIDER: S-EPMC11002274 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Publications

Association of adrenal steroids with metabolomic profiles in patients with primary and endocrine hypertension.

Knuchel Robin R Erlic Zoran Z Gruber Sven S Amar Laurence L Larsen Casper K CK Gimenez-Roqueplo Anne-Paule AP Mulatero Paolo P Tetti Martina M Pecori Alessio A Pamporaki Christina C Langton Katharina K Peitzsch Mirko M Ceccato Filippo F Prejbisz Aleksander A Januszewicz Andrzej A Adolf Christian C Remde Hanna H Lenzini Livia L Dennedy Michael M Deinum Jaap J Jefferson Emily E Blanchard Anne A Zennaro Maria-Christina MC Eisenhofer Graeme G Beuschlein Felix F

Frontiers in endocrinology 20240326

<h4>Introduction</h4>Endocrine hypertension (EHT) due to pheochromocytoma/paraganglioma (PPGL), Cushing's syndrome (CS), or primary aldosteronism (PA) is linked to a variety of metabolic alterations and comorbidities. Accordingly, patients with EHT and primary hypertension (PHT) are characterized by distinct metabolic profiles. However, it remains unclear whether the metabolomic differences relate solely to the disease-defining hormonal parameters. Therefore, our objective was to study the assoc ...[more]

PMID: 38596218

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Dataset Information

Association of adrenal steroids with metabolomic profiles in patients with primary and endocrine hypertension.

Introduction

Methods

Results

Discussions

Publications

Association of adrenal steroids with metabolomic profiles in patients with primary and endocrine hypertension.

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