The associations of serum vitamin D status and vitamin D supplements use with all-cause dementia, Alzheimer's disease, and vascular dementia: a UK Biobank based prospective cohort study.

ABSTRACT:

Background

Prior studies on vitamin D and dementia outcomes yielded mixed results and had several important limitations.

Objectives

We aimed to assess the associations of both serum vitamin D status and supplementation with all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VD) incidence.

Methods

With a prospective cohort study design, we comprehensively assessed the associations of vitamin D and multivitamin supplementation, as well as vitamin D deficiency {25-hydroxyvitamin D [25(OH)D] <30 nmol/L}, and insufficiency [25(OH)D 30 to <50 nmol/L], with the 14-year incidence of all-cause dementia, AD, and VD in 269,229 participants, aged 55 to 69, from the UK Biobank.

Results

Although 5.0% reported regular vitamin D use and 19.8% reported multivi

SUBMITTER: Chen LJ 

PROVIDER: S-EPMC11007746 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature