Mapping intracellular NAD content in entire human brain using phosphorus-31 MR spectroscopic imaging at 7 Tesla.

ABSTRACT:

Introduction

Nicotinamide adenine dinucleotide (NAD) is a crucial molecule in cellular metabolism and signaling. Mapping intracellular NAD content of human brain has long been of interest. However, the sub-millimolar level of cerebral NAD concentration poses significant challenges for in vivo measurement and imaging.

Methods

In this study, we demonstrated the feasibility of non-invasively mapping NAD contents in entire human brain by employing a phosphorus-31 magnetic resonance spectroscopic imaging (³¹P-MRSI)-based NAD assay at ultrahigh field (7 Tesla), in combination with a probabilistic subspace-based processing method.

Results

The processing method achieved about a 10-fold reduction in noise over raw measurements, resulting in remarkably reduced

SUBMITTER: Guo R 

PROVIDER: S-EPMC11190064 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature