Dataset Information

The causal relationship between diet habits and cholelithiasis: a comprehensive Mendelian randomization (MR) study.

ABSTRACT:

Background

Epidemiological studies show dietary habits can have an impact on the risk of cholelithiasis, but the relationship is still unclear. We used a comprehensive Mendelian randomization (MR) study to explore the relationship between dietary habits and cholelithiasis.

Methods

The 18 dietary habits were divided into six categories: meat foods, cereals, vegetables, fruits, dairy products, beverages, and condiments. Cholelithiasis data came from a GWAS meta-analysis and the FinnGen consortium. The inverse variance weighted (IVW), the weighted median (WM), and MR-Egger approaches were used as the main MR analysis methods. In addition, multiple sensitivity analysis and meta-analysis were performed to verify the robustness of the results.

Results

Dried fruit intake [odds ratio (OR) = 0.568; 95% confidence interval (CI), 0.405-0.797; p = 0.001] was discovered to reduce the risk of cholelithiasis. The sensitivity analysis and meta-analysis showed reliable results for the relationship between dried fruit intake and cholelithiasis.

Conclusion

Our study found that dried fruit intake is a protective factor in the development of cholelithiasis. However, the mechanisms of action need to be further explored.

SUBMITTER: Xie L

PROVIDER: S-EPMC11203601 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Publications

The causal relationship between diet habits and cholelithiasis: a comprehensive Mendelian randomization (MR) study.

Xie Lin L Xu Mingzhi M Lei Yahan Y Li Juan J Xie Jiajia J

Frontiers in nutrition 20240612

<h4>Background</h4>Epidemiological studies show dietary habits can have an impact on the risk of cholelithiasis, but the relationship is still unclear. We used a comprehensive Mendelian randomization (MR) study to explore the relationship between dietary habits and cholelithiasis.<h4>Methods</h4>The 18 dietary habits were divided into six categories: meat foods, cereals, vegetables, fruits, dairy products, beverages, and condiments. Cholelithiasis data came from a GWAS meta-analysis and the Finn ...[more]

PMID: 38933877

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Dataset Information

The causal relationship between diet habits and cholelithiasis: a comprehensive Mendelian randomization (MR) study.

Background

Methods

Results

Conclusion

Publications

The causal relationship between diet habits and cholelithiasis: a comprehensive Mendelian randomization (MR) study.

Similar Datasets

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