The causal relationship between diet habits and cholelithiasis: a comprehensive Mendelian randomization (MR) study.

ABSTRACT:

Background

Epidemiological studies show dietary habits can have an impact on the risk of cholelithiasis, but the relationship is still unclear. We used a comprehensive Mendelian randomization (MR) study to explore the relationship between dietary habits and cholelithiasis.

Methods

The 18 dietary habits were divided into six categories: meat foods, cereals, vegetables, fruits, dairy products, beverages, and condiments. Cholelithiasis data came from a GWAS meta-analysis and the FinnGen consortium. The inverse variance weighted (IVW), the weighted median (WM), and MR-Egger approaches were used as the main MR analysis methods. In addition, multiple sensitivity analysis and meta-analysis were performed to verify the robustness of the results.

Results

Dried fruit intake [od

SUBMITTER: Xie L 

PROVIDER: S-EPMC11203601 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature