Dysfunction of CD8⁺ T cells around tumor cells leads to occult lymph node metastasis in NSCLC patients.

ABSTRACT: Occult lymph node metastasis (OLNM) is one of the main causes of regional recurrence in inoperable N₀ non-small cell lung cancer (NSCLC) patients following stereotactic ablation body radiotherapy (SABR) treatment. The integration of immunotherapy and SABR (I-SABR) has shown preliminary efficiency in mitigating this recurrence. Therefore, it is necessary to explore the functional dynamics of critical immune effectors, particularly CD8⁺ T cells in the development of OLNM. In this study, tissue microarrays (TMAs) and multiplex immunofluorescence (mIF) were used to identify CD8⁺ T cells and functional subsets (cytotoxic CD8⁺ T cells/predysfunctional CD8⁺ T cells (CD8⁺ T_predys)/dysfunctional CD8⁺ T cells (CD

SUBMITTER: Li C 

PROVIDER: S-EPMC11309950 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature