Lymph node ?? and ?? CD8+ T cells share migratory properties.

ABSTRACT: During immune responses, T cells differentiate into subsets with different functions and migratory properties. Here we characterize migratory behavior of endogenous ?? CD8+ and ?? T cells in lymph nodes by long-term tracking following in vivo photoconversion. We identified subsets of ?? T cells with distinct circulation kinetics that closely mirrored migratory subsets of ?? CD8+ T cells. Notably, ?? CD8+ and ?? T cells both comprised resident populations which stayed in lymph nodes for 4 weeks without circulation or proliferation. Furthermore, in contrast to the common conception, we observed that central memory ?? CD8+ T cells circulate with slower kinetics than naïve cells. Our results show that, similar to ?? T cells, ?? T cells can acquire distinct migratory properties during their development and differentiation and reveal unexpected intricacies of T cell migratory patterns.

SUBMITTER: Ugur M 

PROVIDER: S-EPMC5997669 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature