Lymph node γδ and αβ CD8⁺ T cells share migratory properties.

ABSTRACT: During immune responses, T cells differentiate into subsets with different functions and migratory properties. Here we characterize migratory behavior of endogenous αβ CD8⁺ and γδ T cells in lymph nodes by long-term tracking following in vivo photoconversion. We identified subsets of γδ T cells with distinct circulation kinetics that closely mirrored migratory subsets of αβ CD8⁺ T cells. Notably, αβ CD8⁺ and γδ T cells both comprised resident populations which stayed in lymph nodes for 4 weeks without circulation or proliferation. Furthermore, in contrast to the common conception, we observed that central memory αβ CD8⁺ T cells circulate with slower kinetics than naïve cells. Our results show that, similar to αβ T cells, γδ T cells can acquire di

SUBMITTER: Ugur M 

PROVIDER: S-EPMC5997669 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature