Calcium homeostasis and endometriosis: A Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have investigated the correlation between calcium homeostasis modulator levels and endometriosis risk. Yet, the genetic association between body calcium homeostasis and endometriosis risk remains to be elucidated.

Methods

Four tiers of Mendelian randomization (MR) analysis were conducted, as follows: (1) single univariate MR and (2) multivariate MR to evaluate the correlation between calcium homeostasis regulators and endometriosis; (3) inverse MR to probe the influence of endometriosis on body calcium homeostasis; (4) two-sample MR to scrutinize the connection between calcium levels and endometriosis categories.

Results

The two-sample MR analysis unveiled a robust positive correlation between genetically inferred calcium leve

SUBMITTER: Deng ZM 

PROVIDER: S-EPMC11336440 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature