A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort.

ABSTRACT: The contributing genetic factors of vertigo remain poorly characterized, particularly in individuals of non-European ancestries. Here we show the genetic landscape of vertigo in an Asian population-based cohort. In a two-stage genome-wide association study (N_case = 6199; N_control = 54,587), we identify vertigo-associated genomic loci in DROSHA and ZNF91/LINC01224, with the latter replicating the findings in European ancestries. Gene-based association testing corroborates these findings. Interestingly, both genes are enriched in cerebellum, a key structure receiving sensory input from the vestibular system. Subjects carrying risk alleles from lead SNPs of DROSHA and ZNF91 incur a 1.74-fold risk of vertigo than those without. Moreover, composite clinical-polygenic risk

SUBMITTER: Chen SP 

PROVIDER: S-EPMC11341872 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature