Proliferation of MDSCs may indicate a lower ^CD4+ T cell immune response in schistosomiasis japonica.

ABSTRACT:

Background

Schistosoma japonicum (S. japonicum) is the main species of Schistosoma prevalent in China. Myeloid-derived suppressor cells (MDSCs) are important immunoregulatory cells and generally expand in parasite infection, but there is little research relating to MDSCs in Schistosoma infection.

Methods

Fifty-six S. japonicum-infected patients were included in this study. MDSCs and percentages and absolute cell numbers of lymphocyte subsets, including ^CD3+ T cells, ^CD4+ T cells, ^CD8+ T cells, B cells and natural killer (NK) cells were detected using flow cytometry. The degree of liver fibrosis was determined using color Doppler ultrasound.

Results

Patients infected with S. japonicum had a much higher percentage of MDSCs among peripher

SUBMITTER: Peng B 

PROVIDER: S-EPMC11363901 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature