Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study.

ABSTRACT: Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale structural alterations in schizophrenia relate to normative structural and functional connectome architecture, and systematically evaluated robustness and generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2439 adults with schizophrenia and 2867 healthy controls from 26 ENIGMA sites and normative data from the Human Connectome Project (n = 207), we evaluated structural alterations of schizophrenia against two network susceptibility models: (i) hub vulnerability, which examines associations between regional network cent

SUBMITTER: Georgiadis F 

PROVIDER: S-EPMC11371638 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature