Effect of 21 different nitrogen sources on global gene expression in the yeast Saccharomyces cerevisiae.

ABSTRACT: We compared the transcriptomes of Saccharomyces cerevisiae cells growing under steady-state conditions on 21 unique sources of nitrogen. We found 506 genes differentially regulated by nitrogen and estimated the activation degrees of all identified nitrogen-responding transcriptional controls according to the nitrogen source. One main group of nitrogenous compounds supports fast growth and a highly active nitrogen catabolite repression (NCR) control. Catabolism of these compounds typically yields carbon derivatives directly assimilable by a cell's metabolism. Another group of nitrogen compounds supports slower growth, is associated with excretion by cells of nonmetabolizable carbon compounds such as fusel oils, and is characterized by activation of the general control of amino acid biosynth

SUBMITTER: Godard P 

PROVIDER: S-EPMC1899933 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature