The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes.

ABSTRACT:

Context

The prevalence of type 2 diabetes (T2D), particularly among young adults, has been rising steadily during the past 2 decades. T2D, especially in its early-onset subtype, is under genetic control. TRIB3 inhibits insulin-stimulated Akt phosphorylation and subsequent insulin action. A TRIB3 gain-of-function polymorphism, Q84R (rs2295490), impairs insulin signaling.

Objective

The objective of the study was to verify the association of TRIB3 Q84R with: 1) T2D, either subtyped or not according to age at diagnosis (early-onset, <45 yr, or >or= 45 yr); 2) insulin secretion and sensitivity in nondiabetic individuals; or 3) in vitro insulin secretion from isolated human islets.

Design

Four different case-control samples comprising a total of 5,469 whites were examined.

SUBMITTER: Prudente S 

PROVIDER: S-EPMC2630876 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature