A combination of misoprostol and estradiol for preoperative cervical ripening in postmenopausal women: a randomised controlled trial.

ABSTRACT:

Objective

To compare the impact of 1000 microg of self-administered vaginal misoprostol versus self-administered vaginal placebo on preoperative cervical ripening after 2 weeks of pretreatment with estradiol vaginal tablets in postmenopausal women prior to day-care operative hysteroscopy.

Design

Randomised, double-blind, placebo-controlled sequential trial.

Setting

Norwegian university teaching hospital.

Population

Sixty-seven postmenopausal women referred for day-care operative hysteroscopy.

Methods

The women were randomised to receive either 1000 microg of self-administered vaginal misoprostol or self-administered vaginal placebo on the evening before day-care operative hysteroscopy. All women had administered a 25-microg vaginal estradiol tablet daily

SUBMITTER: Oppegaard KS 

PROVIDER: S-EPMC2805871 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature